Chung Lab for Anti-Aging Research
Ki Wung Chung, Ph.D.
Associate Professor
College of Pharmacy, Pusan National University
63 Beon-gil 2, Busandaehag-ro, Geumjeong-gu, Busan 46241, Korea
Tel: +82-51-510-2819
E-mail: kieungc@pusan.ac.kr
주저자 및 교신저자 (First & Corresponding author)
PAR2-mediated cellular senescence promotes inflammation and fibrosis in aging and chronic kidney disease
Aging Cell. 2024 Apr 30:e14184.
Ha S, Kim HW, Kim KM, Kim BM, Kim J, Son M, Kim D, Kim MJ, Yoo J, Yu HS, Jung YS, Lee J, Chung HY, Chung KW
Thiobarbiturate-Derived Compound MHY1025 Alleviates Renal Fibrosis by Modulating Oxidative Stress, Epithelial Inflammation, and Fibroblast Activation
Antioxidants (Basel). 2023 Oct 31;12(11):1947.
Kim J, Lee J, Yoon D, Son M, Kim MJ, Ha S, Kim D, Yoo JA, Kim D, Chung HY, Moon HR, Chung KW
TLR7 activation by miR-21 promotes renal fibrosis by activating the pro-inflammatory signaling pathway in tubule epithelial cells
Cell Commun Signal. 2023 Aug 18;21(1):215.
Kim J, Ha S, Son M, Kim D, Kim MJ, Kim B, Kim D, Chung HY, Chung KW
Chronic Inflammation as an Underlying Mechanism of Ageing and Ageing-Related Diseases
Subcell Biochem. 2023;103:31-44.
Chung KW, Kim DH, Jung HJ, Arulkumar R, Chung HY, Yu BP
PPAR Pan Agonist MHY2013 Alleviates Renal Fibrosis in a Mouse Model by Reducing Fibroblast Activation and Epithelial Inflammation
Int J Mol Sci. 2023 Mar 2;24(5):4882.
Son M, Kim GY, Yang Y, Ha S, Kim J, Kim D, Chung HY, Moon HR, Chung KW
Diminished tubule epithelial farnesoid X receptor expression exacerbates inflammation and fibrosis response in aged rat kidney
J Gerontol A Biol Sci Med Sci. 2023 Jan 26;78(1):60-68.
Ha S, Yang Y, Kim BM, Kim J, Son M, Kim D, Kim MJ, Im DS, Chung HY, Chung KW
Activation of PAR2 promotes high-fat diet-induced renal injury by inducing oxidative stress and inflammation
Biochim Biophys Acta Mol Basis Dis. 2022 Oct 1;1868(10):166474.
Ha S, Yang Y, Kim BM, Kim J, Son M, Kim D, Yu HS, Im DS, Chung HY, Chung KW
Immune-related pathogenesis and therapeutic strategies of nonalcoholic steatohepatitis
Arch Pharm Res 2022 Apr;45(4):229-244.
Chung KW, Cho YE, Kim SJ, Hwang S
Renal tubular PAR2 promotes interstitial fibrosis by increasing inflammatory responses and EMT process
Arch Pharm Res 2022 Mar;45(3):159-173.
Ha S, Chung KW*, Lee J, Chung HY, Moon HR
(* Co-first author)
Targeting fatty acid metabolism for fibrotic disorders
Arch Pharm Res 2021 Oct;44:839-856.
Hwang S, Chung KW*
(* Corresponding author)
Comparison of two different toxin-induced kidney fibrosis models in terms of inflammatory responses
Toxicology 2021 Nov;463:152973.
Yang YJ, Ha S, Jeong S, Jang CW, Kim J, Im D, Chung HY, Chung KW*
(* Corresponding author)
Synergistic effect of copper and amino acid mixtures on the production of extracellular matrix proteins in skin fibroblasts
Mol Biol Rep. 2021 Apr;48(4):3277-3284.
Chung KW*, Song SH, Kim MS.
(* Corresponding author)
PAR2 promotes high-fat diet-induced hepatic steatosis by inhibiting AMPK-mediated autophagy
J Nutr Biochem. 2021 Sep;95:108769.
Kim BM, Kim DH, Park YJ, Ha S, Choi YJ, Yu HS, Chung KW*, Chung HY*.
(* Co-corresponding author)
Cells 2021 Apr;13:10(4):880.
Chung KW
Short-term intake of high fat diet aggravates renal fibrosis in aged Sprague-Dawley rats
Exp Gerontol. 2020 Dec;142:111108.
Ha S, Kim MJ, Kim DH, Kim BM, Chung KW*, Chung HY*.
(* Co-corresponding author)
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis
Cell Metab. 2019 Oct 1;30(4):784-799.e5.
Chung KW, Dhillon P, Huang S, Sheng X, Shrestha R, Qiu C, Kaufman BA, Park J, Pei L, Baur J, Palmer M, Susztak K.
The Effects of Calorie Restriction on Autophagy: Role on Aging Intervention
Nutrients. 2019 Dec 2;11(12):2923.
Chung KW, Chung HY.
PPARα/β Activation Alleviates Age-Associated Renal Fibrosis in Sprague Dawley Rats
J Gerontol A Biol Sci Med Sci. 2020 Feb 14;75(3):452-458.
Chung KW, Ha S, Kim SM, Kim DH, An HJ, Lee EK, Moon HR, Chung HY.
Impairment of PPAR α and the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging
J Am Soc Nephrol. 2018 Apr;29(4):1223-1237.
Chung KW, Lee EK, Lee MK, Oh GT, Yu BP, Chung HY.
Evaluation of Antimelanogenic Activity and Mechanism of Galangin in Silico and in Vivo
Biol Pharm Bull. 2018;41(1):73-79.
Chung KW, Jeong HO, Lee EK, Kim SJ, Chun P, Chung HY, Moon HR.
The critical role played by endotoxin-induced liver autophagy in the maintenance of lipid metabolism during sepsis
Autophagy. 2017 Jul 3;13(7):1113-1129.
Chung KW, Kim KM, Choi YJ, An HJ, Lee B, Kim DH, Lee EK, Im E, Lee J, Im DS, Yu BP, Chung HY.
공저자 (Coauthor)
Senoinflammation: A major mediator underlying age-related metabolic dysregulation
Exp Gerontol. 2020 Feb 27;134:110891.
Kim DH, Bang E, Arulkumar R, Ha S, Chung KW, Park MH, Choi YJ, Yu BP, Chung HY.
Novel Role of Lck in Leptin-Induced Inflammation and Implications for Renal Aging
Aging Dis. 2019 Dec 1;10(6):1174-1186.
Kim DH, Park JW, Jeong HO, Lee B, Chung KW, Lee Y, Jung HJ, Hyun MK, Lee AK, Kim BM, Yu BP, Chung HY.
DNMT1 in Six2 Progenitor Cells Is Essential for Transposable Element Silencing and Kidney Development
J Am Soc Nephrol. 2019 Apr;30(4):594-609.
Li SY, Park J, Guan Y, Chung K, Shrestha R, Palmer MB, Susztak K.
Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept
Aging Dis. 2019 Apr 1;10(2):367-382.
Chung HY, Kim DH, Lee EK, Chung KW, Chung S, Lee B, Seo AY, Chung JH, Jung YS, Im E, Lee J, Kim ND, Choi YJ, Im DS, Yu BP.
Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming
PLoS Biol. 2018 Sep 18;16(9):e2005233.
Huang S, Park J, Qiu C, Chung KW, Li SY, Sirin Y, Han SH, Taylor V, Zimber-Strobl U, Susztak K.
Isolation of tyrosinase and melanogenesis inhibitory flavonoids from Juniperus chinensis fruits
Biosci Biotechnol Biochem. 2018 Dec;82(12):2041-2048.
Park SA, Jegal J, Chung KW, Jung HJ, Noh SG, Chung HY, Ahn J, Kim J, Yang MH.
A PPAR Pan Agonist, MHY2013 Alleviates Age-Related Hepatic Lipid Accumulation by Promoting Fatty Acid Oxidation and Suppressing Inflammation
Biol Pharm Bull. 2018;41(1):29-35.
An HJ, Lee B, Kim SM, Kim DH, Chung KW, Ha SG, Park KC, Park YJ, Kim SJ, Yun HY, Chun P, Yu BP, Moon HR, Chung HY.
Quantitative Proteomic Analysis of Changes Related to Age and Calorie Restriction in Rat Liver Tissue
Proteomics. 2018 Mar;18(5-6):e1700240.
Kim Y, Kwon OK, Chae S, Jung HJ, Ahn S, Jeon JM, Sung E, Kim S, Ki SH, Chung KW, Chung HY, Jung YS, Hwang DH, Lee S.
The Standardized Extract of Juniperus communis Alleviates Hyperpigmentation in Vivo HRM-2 Hairless Mice and in Vitro Murine B16 Melanoma Cells
Biol Pharm Bull. 2017;40(9):1381-1388.
Jegal J, Chung KW, Chung HY, Jeong EJ, Yang MH.
Small RNAs induce the activation of the pro-inflammatory TLR7 signaling pathway in aged rat kidney
Aging Cell. 2017 Oct;16(5):1026-1034.
Lee EK, Chung KW, Kim YR, Ha S, Kim SD, Kim DH, Jung KJ, Lee B, Im E, Yu BP, Chung HY.
Effect of betaine on hepatic insulin resistance through FOXO1-induced NLRP3 inflammasome
J Nutr Biochem. 2017 Jul;45:104-114.
Kim DH, Kim SM, Lee B, Lee EK, Chung KW, Moon KM, An HJ, Kim KM, Yu BP, Chung HY.
PPARα activation by MHY908 attenuates age-related renal inflammation through modulation of the ROS/Akt/FoxO1 pathway
Exp Gerontol. 2017 Jun;92:87-95.
Kim YR, Lee EK, Kim DH, Kim KM, Lee B, An HJ, Park JW, Moon KM, Park MH, Chung KW, Park JY, Kim SJ, Yun HY, Son S, Chun P, Moon HR, Chung HY.
Neuroprotective effects of 2,4-dinitrophenol in an acute model of Parkinson's disease
Brain Res. 2017 May 15;1663:184-193.
Lee Y, Heo G, Lee KM, Kim AH, Chung KW, Im E, Chung HY, Lee J.